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Laboratory Genetics and Genomics Fellowship Training

The IU School of Medicine Department of Medical and Molecular Genetics offers training in Laboratory Genetics and Genomics (LGG) which leads to eligibility for certification by the American Board of Medical Genetics and Genomics (ABMGG).

Laboratory Genetics and Genomics is a new specialty of the ABMGG which incorporates training in the Clinical Cytogenetics, Clinical Molecular Genetics, and Clinical Pharmacogenomics laboratories.

How to Apply

For questions about program admissions or to submit application materials, email the Department of Medical and Molecular Genetics Education Programs Manager.

Curriculum

The training period is 30 months with an option for an additional six months. Upon completion of 30 months of training, individuals may apply to the ABMGG for eligibility for the certification examination in Laboratory Genetics and Genomics.

In addition to experience gained in clinical cytogenetics, clinical molecular genetics, and pharmacogenomics, Laboratory Genetics and Genomics fellows are instructed on how to validate and establish new testing; implement quality control practices; and establish, review and maintain standard operating procedures. Fellows also rotate through a month of Medical Genetics clinics each year of training.

Explore the Laboratory Genetics and Genomics Learning Guide for specifics.

Admissions

Our next cycle for LGG fellowship training starts July of 2025. Applications should be submitted by August 31, 2024, which should include the following:

  • Current resume
  • Personal statement
  • Three letters of recommendation sent directly to the program at iugtllgg@iu.edu.

Incomplete applications at the time of the deadline will not be considered.

Program Progression

Year 1

Content  July August September/
October
November/
December
January/
February
March/
April
May June
Block Cytogenetics Block 1  Molecular Genetics Block 1
Core Training

Orientation
Pre-Analytics – Week 1

Blood setup and culture

Cytogenetic test cases/
scoping

Prenatal/ POC setup and culture

Cytogenetic test cases/
scoping

Blood/ prenatal/ POC analysis and interpretation

CMA wet lab/ analysis

FISH wet lab and scoping

Cancer setup and culture

Orientation – Week 1
Pre-analytics

DNA extraction

RNA assays

STR

MLPA

Trinucleotide Repeat Expansion

Sanger
Sequencing

NGS Introduction

Molecular case review and sign-outs

Research
Proposal

Site 1 1 1 1 1 1 1 1
Other Training    

Read 1/2 cases constitutional cases; participate in CMA analysis, interpretation and report

Interpretation. Integrate FISH with constitutional cases and CMA; provide
Understand the FISH/Cancer cytogenetics workflow- read FISH cases and integrate with G-band
In-service exam   Test validation Medical Genetics Clinic
Site     1 1 1   1 2 and 3
Didactics   Monthly in-service

Q613 - Molecular & Biochemistry Laboratory

Q625 - Introduction to Clinical Genetics

Q620 - Human Cytogenetics/Q630 Population Genetics

Q630 - Population Genetics

 

 

Year 2

Content July August September/
October
November/
December
January/
February/
March
April May June
Block Cytogenetics Block 2 Molecular Genetics Block 2
Core Training CMA analysis/ interpretation/ reporting Cancer chromosome and FISH analysis/ interpretation/ reporting  NGS Pathology laboratory rotation Pharmacogenomics/ Open Array
Site 1 1 1 4 1
Other Training Medical Genetics Clinic/URDC Newborn Screen Laboratory Integration of Prenatal with Cytogenetics, FISH and CMA; Read FISH and G-band Cancer cases; provide interpretation

Take Laboratory Calls and Consultations

Prenatal Genetic Counseling

In-service exam

NGS 101 (AMP)

Research

NGS

Research

Pharmacogenomics: Genes, Drugs, and Genotyping - AMP

Research

Research
Site 2 and 3 1 3 1 1 1
Didactics

Lab Administration certificate course (AMP)

Monthly
In-Service

Q600 - Practical Prenatal Genetic Counseling
Q612-Molecular and Biochemistry Didactics
   

 

Year 3

Content July August-December
Block Biochemical genetics rotation Area of concentration in cytogenetics, molecular, pharmacogenomics or NGS
Core Training  

Case sign-outs for cytogenetics/ molecular/ pharmacogenomics/ diagnostic genomics (NGS) laboratories (rotate weekly-primary responsibility)

CAP QA/QC for cytogenetics/ molecular/ pharmacogenomics/ diagnostic genomics (NGS) laboratories

Site 1 1
Other Training Research/ teaching/ test validation

Manuscript submission

Research/ teaching/ test validation

Site 1 1
Didactics   Course lectures/ department seminar

 

NOTE: Each fellow has a two week vacation time per year that can be scheduled in coordination with the program director.


Site Key

Site 1: IU Genetic Testing Lab

Site 2: IU Health University Hospital

Site 3: Riley Children's Hospital

Site 4: IU Health Pathology Lab


Abbreviations

Product of conception (POC), Chromosomal microarray (CMA), Fluorescence in situ hybridization (FISH), Short tandem repeat (STR) testing, Multiplex Ligation-dependent Probe Amplification (MLPA), Next generation sequencing (NGS), Undiagnosed Rare Disease Clinic (URDC), Association for Molecular Pathology (AMP), College of American Pathologists (CAP), Quality Assurance (QA), Quality Control (QC)